![]() ![]() However, the commercialization and the clinical deployment of AO-OCT are still challenging, mainly because of cost, optical complexity, size and heavy image post-processing linked to the use of AO. To be able to combine both high axial resolution from OCT, and the high lateral resolution from AO, a great effort was made to develop AO-OCT systems. By correcting static and dynamic ocular aberrations, AO can explore the full aperture of the eye’s pupil to achieve micrometer lateral resolution. Although OCT can produce en-face retinal images from 3-D stacks, it presents a low lateral resolution compared with Adaptive Optics (AO) ophthalmoscopes. While physicians are capable of interpreting tomographic retinal cross-sections from OCT, there is nevertheless a demand for en-face views. Owing to its unprecedented axial resolution, OCT enables the diagnosis of retinal disorders at the earliest stages and monitoring of the progression of retinal diseases. Optical Coherence Tomography (OCT) has become a gold standard for living human retinal imaging in the clinical environment. By these means, we demonstrate the capacity of the FF-OCT to resolve cone mosaic as close as 1.5 o from the fovea center with high consistency and without using adaptive optics. Closed-loop optical stabilization reduced the RMS error by a factor of 7, significantly increasing the FF-OCT image acquisition efficiency. B-scans generated by the SD-OCT were used to measure the retina axial position and to drive the position of the high-speed voice coil translation stage, where the FF-OCT reference arm is mounted. This was made possible by combining an FF-OCT system, an SD-OCT system, and a high-speed voice-coil translation stage. In this paper, we demonstrate a solution to this problem by implementing an optical stabilization in an FF-OCT system. One of the biggest challenges to transfer this technique to image in-vivo human retina is the presence of continuous involuntary head and eye axial motion during image acquisition. ![]() ![]() Time-domain full-field OCT (FF-OCT) represents an imaging modality capable of recording high-speed en-face sections of a sample at a given depth. ![]()
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